Physical Pharmaceutics–II (4th Semester, 2nd Year) is a comprehensive academic book designed specifically for Bachelor of Pharmacy (B.Pharm) students in accordance with the pharmacy curriculum. The book aims to provide a clear and systematic understanding of important physicochemical principles that influence the design, formulation, and performance of pharmaceutical dosage forms. The content of this book is structured to help students develop strong fundamental knowledge of physical pharmacy concepts and their practical applications in pharmaceutical sciences. It covers key topics such as complexation, protein binding, dissolution and drug release kinetics, diffusion principles, interfacial phenomena, surface and interfacial tension, adsorption, rheology, and micromeritics, which play a crucial role in drug formulation and development. Each chapter explains theoretical concepts in a simple and student-friendly manner, supported by relevant examples and diagrams to enhance understanding. Special attention has been given to explaining the pharmaceutical significance of physicochemical properties, helping students understand how these principles affect drug stability, bioavailability, and therapeutic effectiveness. The book also includes illustrative examples, important definitions, and conceptual explanations to assist students in preparing for university examinations and competitive pharmacy exams. This book serves as a valuable resource for B.Pharm 2nd year students (4th semester), teachers, and pharmacy professionals who seek a clear and concise reference for physical pharmaceutics. By integrating theoretical knowledge with pharmaceutical applications, Physical Pharmaceutics–II aims to strengthen students’ conceptual understanding and support their academic as well as professional development in the field of pharmaceutical sciences.